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Symbol
Name
ID

Il6st
interleukin 6 signal transducer
MGI:96560

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Eosinophilia
Disease(s) Associated with IL6ST	Increased circulating IgE level	Eosinophilia
hyper IgE recurrent infection syndrome 4

Mouse Phenotypes

abnormal osteoclast differentiation

thymus hypoplasia

decreased thymocyte number

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal common myeloid progenitor cell morphology

decreased common myeloid progenitor cell number

abnormal erythropoiesis

abnormal T cell differentiation

abnormal T cell clonal deletion

increased double-negative T cell number

decreased double-positive T cell number

abnormal thrombopoiesis

anemia

abnormal bone marrow cell morphology/development

abnormal megakaryocyte morphology

decreased megakaryocyte cell number

increased megakaryocyte cell number

decreased erythroid progenitor cell number

increased mean corpuscular hemoglobin concentration

increased nucleated erythrocyte cell number

increased neutrophil cell number

thrombocytopenia

abnormal leukocyte cell number

decreased B-1a cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased activated T cell number

increased single-positive T cell number

increased osteoclast cell number

increased leukocyte cell number

decreased hematopoietic stem cell number

abnormal osteoclast morphology

abnormal B cell physiology

abnormal immunoglobulin level

decreased IgA level

increased IgA level

increased IgE level

decreased IgG1 level

increased IgG1 level

decreased IgG2a level

increased IgG2a level

decreased IgG2b level

increased IgG2b level

decreased IgG level

increased IgG level

increased IgM level

decreased immunoglobulin level

abnormal T cell activation

abnormal osteoclast physiology

Availability

Mouse Genotype

Il6st^tm1Ard/Il6st^tm1Ard

Il6st^tm1Ern/Il6st^tm1Ern

Il6st^tm1Kish/Il6st^tm1Kish

Il6st^tm1Thir/Il6st^tm1Thir

Il6st^tm1Wme/Il6st^tm1Wme

Il6st^tm2Thir/Il6st^tm2Thir

Il6st^tm3Thir/Il6st^tm3Thir

Il6st^{tm1b(KOMP)Mbp}/Il6st⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23